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Dento Maxillo Facial Radiology 2013Benign mesenchymoma is a soft tissue neoplasm composed of an admixture of two or more benign mesenchymal components in addition to fibrous tissue. A rare case of benign...
Benign mesenchymoma is a soft tissue neoplasm composed of an admixture of two or more benign mesenchymal components in addition to fibrous tissue. A rare case of benign mesenchymoma of the infratemporal space in a 14-year-old boy is presented. In this case report we discuss the salient imaging and histopathological features of this rare entity.
Topics: Adolescent; Cranial Fossa, Middle; Humans; Male; Mandible; Maxillary Sinus; Mesenchymoma; Multidetector Computed Tomography; Skull Base Neoplasms; Temporal Bone; Zygoma
PubMed: 22282510
DOI: 10.1259/dmfr/82002914 -
World Journal of Clinical Cases Aug 2022A biliary inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymoma that, although it has a broad age spectrum, usually occurs in adults. Diagnosis is...
BACKGROUND
A biliary inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymoma that, although it has a broad age spectrum, usually occurs in adults. Diagnosis is difficult because biliary IMTs often exhibit nonspecific clinical symptoms and imaging features, resulting in delayed or inappropriate treatment. Although most IMTs are benign, some show malignant properties such as infiltration, recurrence, and metastasis.
CASE SUMMARY
Here, we retrospectively describe a 10-month-old infant who was admitted to our hospital due to stubborn jaundice. The patient responded poorly to routine medical treatment and his clinical manifestations and laboratory tests lacked specificity, so we turned to repeated ultrasound scans and other imaging examinations. As both hepatosplenic ultrasonography and diffusion-weighted magnetic resonance imaging demonstrated a space-occupying lesion, an exploratory laparotomy was performed. The final diagnosis made over two mo after the disease onset was infant biliary cirrhosis caused by a biliary IMT, which partially infiltrated into the liver. This infant is the youngest case of biliary IMTs that has been reported till now. The patient underwent an incomplete resection of the mass and Kasai Portoenterostomy. However, because of cirrhosis, he also received a paternal liver transplant. Since some IMTs show malignant properties, we proceeded with a three-year of follow-up; however, no recurrence or metastasis has been noted.
CONCLUSION
Neoplastic disease such as IMTs should be considered when routine medical treatment of obstructive jaundice is not successful. Observation of dynamic imaging changes is helpful for diagnosis. Periodic follow-up is necessary for IMTs.
PubMed: 36159551
DOI: 10.12998/wjcc.v10.i23.8375 -
Journal of Clinical Pathology May 1983Benign mesenchymoma is a mixed tumour of mesenchymal derivatives composed of a mixture of two or more mesenchymal elements in addition to fibrous tissue. Two cases of...
Benign mesenchymoma is a mixed tumour of mesenchymal derivatives composed of a mixture of two or more mesenchymal elements in addition to fibrous tissue. Two cases of this tumour of the stomach are reported. As far as can be ascertained, there has been no previous report of gastric mesenchymoma.
Topics: Aged; Humans; Male; Mesenchymoma; Stomach Neoplasms
PubMed: 6841644
DOI: 10.1136/jcp.36.5.504 -
Thoracic Surgical Science Aug 2006Benign mesenchymoma is a rare type of germ cell tumour. An extensive literature search revealed only one described case of mediastinal mesenchymoma in Europe and three...
Benign mesenchymoma is a rare type of germ cell tumour. An extensive literature search revealed only one described case of mediastinal mesenchymoma in Europe and three cases in Asia. We describe our recent experience of a mediastinal mesenchymoma and present the fascinating imaging and operative findings. The preoperative diagnosis of these lesions remains difficult and therefore surgical resection is recommended.
PubMed: 21289950
DOI: No ID Found -
Croatian Medical Journal Apr 2008To assess the expression of CD137 and CD137L in human primary tumor tissues and their potential role in tumor immunity.
AIM
To assess the expression of CD137 and CD137L in human primary tumor tissues and their potential role in tumor immunity.
METHODS
Expression of CD137 and CD137L was assessed by immunohistochemistry in frozen sections of 12 human normal tissues, 15 benign tumors of epithelial or mesenchymal origin (adenoma and leiomyoma), and 36 malignant tumors of epithelial origin (squamous cell carcinoma and adenocarcinoma). The expression of CD137L on 9 human tumor cell lines (3 hepatocarcinoma, 2 lung carcinoma, 2 colon carcinoma, 1 lymphoma, and 1 leukemia) was detected by reverse transcription polymerase chain reaction. To analyze the role of CD137L expressed on tumor cells, we co-cultured tumor cells expressing CD137L with activated T lymphocytes expressing CD137 or with Chinese hamster ovary cells expressing CD137 and then detected by ELISA the levels of cytokines (IL-8, IFN-gamma) secreted by tumor cells or activated T cells.
RESULTS
The expression of CD137 and CD137L was observed only in human benign (2/15, 3/15) or malignant tumors (15/36, 21/36), but not in normal tissues (0/12, 0/12). CD137 was expressed on the vessel walls within tumor tissues, whereas CD137L was expressed on tumor cells. The expression of CD137 and CD137L was more common in malignant tumors, especially in moderate or low-differentiated tumors. Furthermore, CD137L expression found on tumor cell lines was functional because the ligation of CD137L on lung squamous carcinoma cells L78 with CD137 on T cells induced IFN-gamma production by T cells, and ligation of CD137L on hepatocarcinoma cells HepG2.2.15 with CD137 triggered tumor cells to produce IL-8.
CONCLUSION
CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors.
Topics: 4-1BB Ligand; Carcinoma; Cell Line, Tumor; Disease Progression; Gene Expression; Humans; Immunohistochemistry; Mesenchymoma; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor Receptor Superfamily, Member 9
PubMed: 18461674
DOI: 10.3325/cmj.2008.2.192 -
Bulletin of the World Health... 1974This is a classification of tumours of fibrous tissue, fat, muscle, blood and lymph vessels, and mast cells, irrespective of the region of the body in which they arise....
This is a classification of tumours of fibrous tissue, fat, muscle, blood and lymph vessels, and mast cells, irrespective of the region of the body in which they arise. Tumours of fibrous tissue are divided into fibroma, fibrosarcoma (including "canine haemangiopericytoma"), other sarcomas, equine sarcoid, and various tumour-like lesions. The histological appearance of the tumours is described and illustrated with photographs.
Topics: Animals; Animals, Domestic; Calcinosis; Cats; Dogs; Histiocytoma, Benign Fibrous; Horses; Keloid; Lipoma; Mesenchymoma; Neoplasms; Neoplasms, Connective Tissue; Neoplasms, Muscle Tissue; Neoplasms, Vascular Tissue; Polyps; Sarcoma
PubMed: 4371740
DOI: No ID Found -
Journal of Clinical Pathology May 2003Gastrointestinal stromal tumours (GISTs) are uncommon mesenchymal neoplasms. Some metastasise, whereas others remain asymptomatic for years, but it is difficult to...
AIM
Gastrointestinal stromal tumours (GISTs) are uncommon mesenchymal neoplasms. Some metastasise, whereas others remain asymptomatic for years, but it is difficult to distinguish between them histologically. This report analyses the characteristics of seven metastasising GISTs and compares clinicopathological parameters of the metastatic and non-metastatic groups.
METHODS/RESULTS
Histology revealed typical GIST features with spindle, epithelioid, or mixed appearance. All seven cases were positive for vimentin, five for neurone specific enolase, six for c-kit, four for S-100, three for PGP-9.5, three for CD-34 and synaptophysin, but all were negative for cytokeratin, neurofilament, chromogranin A, and desmin. Four showed a focal reaction for smooth muscle actin. Three of the tumours were GI, and two each were GII and GIII. The Ki-67 index varied from 4% to 44%, the three GI cases had 4%, 10%, and 16%. Tumours from the metastatic GIST group were significantly larger than those from the non-metastatic group.
CONCLUSIONS
Three cases exhibited bland, GI histological features with moderate or low proliferative activity. Among the c-kit positive metastasising stromal tumours, some were low grade, with moderate or low mitotic and Ki-67 indices, emphasising the necessity to develop a reliable grading system for GIST to predict clinical behaviour, the importance of careful analysis of "benign looking" tumours, and the key role of c-kit status in identifying patients who could benefit from treatment with STI-571. Larger tumours had a higher chance of metastasising, and only the size of the primary tumour played a role in predicting metastatic potential.
Topics: Adult; Aged; Biomarkers, Tumor; Female; Gastrointestinal Neoplasms; Humans; Leiomyosarcoma; Liver Neoplasms; Male; Mesenchymoma; Middle Aged; Mitotic Index; Neoplasm Proteins; Proto-Oncogene Proteins c-kit; Stromal Cells
PubMed: 12719457
DOI: 10.1136/jcp.56.5.363 -
Frontiers in Oncology 2019Ectopic ovaries are a rare occurrence. A 33-year-old woman presented to our unit for evaluation of a 2-year history of sporadic abdominal pain that was becoming sharp...
Ectopic ovaries are a rare occurrence. A 33-year-old woman presented to our unit for evaluation of a 2-year history of sporadic abdominal pain that was becoming sharp and frequent. Computed tomography (CT) suggested a gastrointestinal tract mesenchymoma. An abdominal laparotomy was performed and the tumor was excised for pathologic evaluation. A rapid frozen section pathologic examination showed a solitary fibrous tumor (SFT). The final pathology report was an ectopic ovary with corpora lutea bleeding. Ectopic ovaries are benign and the present case is the first report involving an ectopic ovary mimicking a gastrointestinal stromal tumor (GIST). The patient recovered well after surgery. Maldevelopment of the genital tract can lead to ectopic ovaries and surgery is a good management choice. The present case provides a possible differential diagnosis for GISTs.
PubMed: 31334114
DOI: 10.3389/fonc.2019.00580 -
Annals of the Royal College of Surgeons... Jul 2013Lipomas are the most commonly encountered benign mesenchymal tumour, arising in any location where fat is normally present. Lipomas in the head and neck are rare in all... (Review)
Review
Lipomas are the most commonly encountered benign mesenchymal tumour, arising in any location where fat is normally present. Lipomas in the head and neck are rare in all age groups. Cases of vascular sheath lipomas in the femoral region have only been reported in adults. In children, vascular sheath lipomas have not been described to date. We report the first case of a carotid sheath lipoma in a seven-year-old boy. He had a non-tender soft mass with ill defined borders occupying the left upper part of the neck. Magnetic resonance imaging showed a mass at the bifurcation of the left common carotid artery without involving the same. The mass was hyperintense on T1 and T2 weighted sequences, suggestive of a lipoma. The lipoma was enucleated after incising the carotid sheath, safeguarding its contents. Histopathology confirmed it as a lipoma.
Topics: Carotid Artery, Common; Child; Humans; Lipoma; Male; Mesenchymoma; Neoplasms, Vascular Tissue
PubMed: 23838487
DOI: 10.1308/003588413X13629960045878 -
Abdominal Imaging 2003Endosonographic features of c-kit-positive gastrointestinal stromal tumors (GISTs) were compared with those of leiomyomas and schwannomas. (Comparative Study)
Comparative Study
BACKGROUND
Endosonographic features of c-kit-positive gastrointestinal stromal tumors (GISTs) were compared with those of leiomyomas and schwannomas.
METHODS
Twenty-four patients with gastric mesenchymal tumors who underwent endoscopic ultrasonography (EUS) and surgical treatment were enrolled. GISTs were defined as c-kit (CD117)-positive tumors, leiomyomas as desmin-positive and c-kit-negative tumors, and schwannomas as S-100-positive and c-kit-negative tumors. Invasion to adjacent organs or more than 20 mitotic counts per 50 high power fields indicated malignancy.
RESULTS
There were 19 GISTs, three leiomyomas, and two schwannomas. All five malignant tumors were GISTs. A marginal halo was found in 12 of 19 GISTs and in both of the schwannomas, but not in any of the three leiomyomas. The echogenicities of GISTs were low but higher than that of the normal proper muscle layer, whereas those of leiomyomas and schwannomas were usually low. Lobulation of the tumor surface was documented only in GISTs, particularly in malignant ones. The tumor doubling time of a malignant GIST was 9.3 months, and that of six benign GISTs was 18.7 months (range = 10.7-28.0 months).
CONCLUSION
Marginal halo and relatively higher echogenicity on EUS might suggest GIST. Marginal lobulation and a short doubling time may be signs of a malignant GIST.
Topics: Endosonography; Female; Gastrointestinal Neoplasms; Humans; Immunohistochemistry; Leiomyoma; Male; Mesenchymoma; Middle Aged; Neurilemmoma; Proto-Oncogene Proteins c-kit
PubMed: 12719898
DOI: 10.1007/s00261-002-0055-x